NSAIDs control the pain and inflammation associated with osteoarthritis.
They work by blocking the production of prostaglandins, the chemicals that cause inflammation, in the COX pathway. COX stands for cyclooxygenase, which is another enzyme in the pathway that breaks down the arachidonic acid in the cell membranes of the joint into chemicals such as free radicals and various prostaglandins that damage the articular cartilage.
Full article Longlife: NSAIDs Research Article
Filed under: Arthritis, NSAIDs
Two NSAIDs generally are not recommended to be administered to the same dog at the same time.
As a result, when it is necessary to switch a dog from one NSAID medication to another, oftentimes a “wash out” period is necessary. The “wash out” period allows the dog’s body to clear the previous drug from its tissues before the new NSAID is administered. This “wash out” period helps reduce the potential for adverse effects from the medications.
Full article Pet Health Care Gazette: Switching Your Dog Safely from One NSAID Medication to Another
Filed under: NSAIDs, Wash out period